Online learning is an innovative tool, which can make the teaching-learning process more learner-centered, more flexible and more exciting. Though, online education is a boon to the education system of any country, but without proper use of technology, it is not proved to be fruitful. For online teaching-learning process, n numbers of technologies are available. All of these technologies are not user-friendly, since they create many difficulties while using them. The difficulties or problems include issues with installation of software, login problems, problems with downloading or uploading and problems related to clarity of audio or video. Many students complain that online learning is boring and un-engaging for them. Hence, a teacher without proper technical knowledge faces problems of using technology in online learning particularly at higher level of education. The selection of proper technology for the teaching- learning process is also not an easy task since every technology has its potentialities and limitations for the accomplishment of specific learning tasks (Koehler and Mishra, 2009). Standing at this juncture, a question arises – how can a teacher integrate technology in his/her teaching effectively? And how to integrate technology, pedagogy and content knowledge in the teaching-learning process? From these, the idea of Technology, Pedagogy and Content Knowledge (TPACK) framework has been evolved. In this paper an attempt has been made to explain how TPACK framework is very much crucial in the online learning to fix many issues related to online learning at higher education level with a few recommendations at concluding section.